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Funding News - Research on the Genetic Variation and Architecture of Complex Phenotypes Sought

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  • The information on this page is for historical and research purposes only.
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The National Institute of Neurological Disorders and Stroke (NINDS) encourages grant applications for research on the genetic variation and architecture of complex phenotypes.*

Complex phenotypes are those that exhibit familial clustering. They may be continuous in distribution, like height or blood pressure, or they may be dichotomous, like affected and not affected. Genetic architecture refers to the full range of genetic effects on a trait. It is less a fixed property of the phenotype than a characteristic of a phenotype in a particular population, and it changes according to gene and genotype frequencies, distributions of environmental factors, and such biological properties as age and sex.

Areas of potential research interest include: variation in basic biological systems, including sequences, structures, and pathways that direct metabolism and development; variation in these systems within individuals, and among individuals, populations, and species with the goal of learning how these complex systems interact and evolve; determination of the extent to which genetic architecture is shared across populations and among species; effects of admixture, population history, recombination, mutation, population structure, selection, and drift on the organization of variation; collection and analysis of both new and existing data; tools and models for identifying and measuring important contextual features; and measuring the impact of context on biological data.

For more information, potential applicants should contact Dr. Katrina Gwinn-Hardy, Program Director, Neurogenetics Cluster, NINDS, Neuroscience Center, 6001 Executive Boulevard, Room 2142, Bethesda, MD 20892; telephone: 301-496-5745; fax: 301-402-1501; e-mail: gwinnk@ninds.nih.gov.

*For a more detailed description of this program announcement, please visit the NIH web site at: http://grants1.nih.gov/grants/guide/pa-files/PA-02-110.html.