The National Institute of Neurological Disorders and Stroke (NINDS), the National Institute of Child Health and Human Development (NICHD), the National Institute of Nursing Research (NINR), the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), and the Juvenile Diabetes Research Foundation International request applications for new approaches to prevent hypoglycemia in patients with diabetes.* The objective of this request for applications (RFA) is to define and characterize hypoglycemia in people with diabetes, and to develop new approaches to prevent the development of hypoglycemia and improve its effects in people with diabetes. Examples of potential areas of research include studies to: determine the prevalence of hypoglycemia in patients with diabetes, with a focus on delineating differences among various age groups (e.g., children, adults, and elderly adults); delineate the role of age, gender, race/ethnicity, socioeconomic status, and other factors on the risk of hypoglycemia; identify factors, including method of treatment, exercise, nutrition, or duration of diabetes, which affect risk of hypoglycemia; establish normative data for blood glucose levels, particularly in children, throughout a 24-hour period; determine whether there are changes in counter-regulatory mechanisms with age; determine whether intensive glucose control during pregnancy has adverse effects on the developing fetus; determine whether alternative fuels (e.g., ketones) can provide a buffer against hypoglycemia; assess the reliability and utility of continuous glucose sensors in detecting falling blood glucose levels and in preventing severe hypoglycemia; determine whether the occurrence of hypoglycemia can be minimized by altering the timing of drug delivery or by drugs with altered kinetics; determine whether different treatment regimens for diabetes affect counter-regulatory mechanisms; evaluate whether there are differences in counter-regulation between individuals with type 1 and type 2 diabetes; and develop and test strategies for minimizing the risk of hypoglycemia with intensive glucose management. APPLICATION RECEIPT DATE: November 21, 2001. For more information, potential applicants should contact Dr. Toby Behar, Program Director, Neural Environment Cluster, NINDS, Neuroscience Center, 6001 Executive Boulevard, Room 2114A, Bethesda, MD 20892; telephone: (301) 496-1431; fax: (301) 480-2424; e-mail: email@example.com.
*For a more detailed description of this RFA, please visit the NIH web site at: http://grants.nih.gov/grants/guide/rfa-files/RFA-DK-01-032.html.