The National Institute of Neurological Disorders and Stroke (NINDS), the National Institute of Mental Health (NIMH), the National Institute on Aging (NIA), the National Institute on Deafness and Other Communication Disorders (NIDCD), and the National Institute on Drug Abuse (NIDA) request applications for cognitive neuroimaging research to understand the link between neuronal activity and functional imaging signals.* The objective of this request for applications (RFA) is to solicit proposals that will increase the utility of functional imaging techniques in the field of cognitive neuroscience by providing greater understanding of the link between hemodynamic effects and underlying neural activity and by improving the ability of these techniques to address questions with a significant temporal component. Examples of potential areas of research include studies to: explore the relationships between synaptic activity, brain metabolic changes, vascular responses, and hemodynamic signals in cortical and subcortical regions; establish a quantitative link between neuronal responses and fMRI signals-relationships of hemodynamic signal to neuronal firing rates and neuronal subthreshold activity; address the issue of spatial homogeneity, sensitivity and variability due to region-specific vasculature and neuronal packaging; couple the MRI technique with other modes of investigation that would directly rule out alternative sources of signal change; combine the techniques of functional neuroimaging with in-vivo single unit electrophysiology or microdialysis in nonhuman primates; demonstrate direct coupling between electrical activity (EEG-MEG) and hemodynamic signals (MRI-optical signal); develop and validate regionally specific computational models of electrical activity and hemodynamic metabolism in nonhuman primates or other relevant animal models; and develop and adapt novel experimental designs employing existing functional imaging techniques in humans to nonhuman primate or other relevant models for the purpose of extending these protocols to studies linking neuronal activity to hemodynamic signal to specifically address the issue of the dynamics of cognitive function. APPLICATION RECEIPT DATE: November 28, 2001. For more information, potential applicants should contact Dr. Emmeline Edwards, Program Director, Systems and Cognitive Neuroscience Cluster, NINDS, 6001 Executive Boulevard, Room 2109, Bethesda, MD 20892; telephone: (301) 496-9964; fax: (301) 402-2060; e-mail: email@example.com.
*For a more detailed description of this RFA, please visit the NIH web site at: http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-02-009.html.