NIH invites grant applications for research on novel statistical methods for human gene expression quantitative trait loci analysis.
This announcement is an NIH Roadmap Initiative. The NIH Roadmap is an innovative approach to accelerate fundamental discovery and translate that knowledge into effective prevention strategies and new treatments.
Genome-wide association studies (GWAS) have shown great promise in identifying genetic loci associated with common human diseases. To date, more than 75 different traits have been significantly associated with more than 900 genetic variants. Many of the GWAS associations identified thus far may be due to subtle effects of genetic variation on gene regulation. The identification of genes whose expression is correlated with specific genetic variants (known as expression quantitative trait loci) can serve as a tool to functionally characterize a disease-associated single nucleotide polymorphism, or SNP, and point to the underlying biological pathways.
Letters of Intent Receipt Date: August 16, 2009
Application Receipt Date: September 16, 2009
Potential applicants should contact Dr. Yin Yao, Division of Neuroscience and Basic Behavioral Science, NIMH; telephone: 301-443-2037; email: firstname.lastname@example.org. For more information visit http://grants.nih.gov/grants/guide/rfa-files/RFA-RM-09-006.html.