The National Institutes of Health (NIH) requests grant applications to establish a molecular libraries screening centers network.*
This request for applications (RFA) is an NIH Roadmap Initiative. The NIH Roadmap is an innovative approach to accelerate fundamental discovery and translate that knowledge into effective prevention strategies and new treatments. All NIH institutes and centers participate in Roadmap Initiatives.*
The molecular libraries screening centers network will be a national resource capable of providing innovative high throughput molecular screening approaches to identify small organic molecules (compounds) that are active in biological assays, and synthetic chemistry to improve the use of these molecules as bioactive probes for in vitro, and potentially in vivo, studies of normal and abnormal physiology of cells, organs, model systems, and/or organisms. The primary objective of this screening effort is to identify compounds that will constitute a new set of research tools for both public and private sector scientists to use. In addition, some of these compounds may be used by scientists as chemical platforms that may lead to new therapeutics.
Potential areas of research interest include: discovery of novel biological targets that can inform studies of cell function and disease pathophysiology; discovery, validation, and application of assays (screens) and disease models to evaluate the activity of novel small molecules; and use of chemical genomic approaches to characterize the biology of genes of interest, cellular processes, and proteins associated with disease processes.
APPLICATION RECEIPT DATE: August 24, 2004
For more information, potential applicants should contact Dr. Linda Brady, Project Team Leader, Molecular Libraries Screening
Centers Network, NIMH, Division of Neuroscience and Basic Behavioral Science, 6001 Executive Boulevard, Room 7185, Bethesda,
MD 20892; telephone: 301-443-5288; fax: 301-402-4740;
*For a more detailed description of this RFA, please visit the NIH web site at: http://grants1.nih.gov/grants/guide/rfa-files/RFA-RM-04-017.html. For more information on the NIH Roadmap, please visit the website at: http://nihroadmap.nih.gov/.