The National Institute of Neurological Disorders and Stroke (NINDS) and the National Institute of Mental Health (NIMH) request grant applications to establish microarray centers for research on the nervous system.*
Oligonucleotide and cDNA microarrays are used to make quantitative or relative measurements of gene expression. The microarrays contain nucleotide sequences corresponding to known genes or expressed sequence tags. A single array can contain thousands of genes, which may represent a significant subset of the genes, or even the entire genome, of an organism. A comparison of cells or tissues from experimental and control preparations provides data on differences in expression levels between the two conditions. Changes in gene expression and expression patterns may reveal clues to underlying, widespread alterations of cellular physiology and/or provide information on developmental or disease processes. Changes in one or a few genes might lead to the discovery of individual molecular targets for drug therapy.
The goal of this request for applications (RFA) is to establish up to three microarray centers that will work together as a consortium, providing NINDS-funded and NIMH-funded investigators with a broad spectrum of services to support microarray analyses on the nervous system. The services will include: providing commercial arrays; producing arrays for use by the neuroscience community; performing array experiments, including hybridization reactions, array reading, and data analyses; and advising and training the neuroscience community, including assisting with experimental design, advising on how best to obtain experimental results, and training neuroscientists on the effective use of microarray experimental techniques, in an effort to disseminate expertise throughout the neuroscience community. The services provided by the centers will be on a fee-for-service basis.
APPLICATION RECEIPT DATE: August 9, 2004
For more information, potential applicants should contact Dr. Thomas Miller, Program Director, Technology Development Cluster, NINDS, Neuroscience Center, 6001 Executive Boulevard, Room 2139, Bethesda, MD 20892; telephone: 301-496-1779; fax: 301-402-1501; e-mail: firstname.lastname@example.org.
*For a more detailed description of this RFA, please visit the NIH web site at: http://grants1.nih.gov/grants/guide/rfa-files/RFA-NS-05-002.html.