The National Institute of Neurological Disorders and Stroke (NINDS), the National Center for Research Resources (NCRR), the National Institute of General Medical Sciences (NIGMS), and the National Heart, Lung, and Blood Institute (NHLBI) encourage Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) grant applications to develop new technology for proteomics and glycomics.*
Proteomics and the subdiscipline of glycomics are rapidly developing, technology-intensive fields. However, technologies and methods in these fields remain largely inadequate to address the majority of meaningful biological problems, particularly with respect to quantitative and real time measurements. Continued intensive development of advanced tools is essential.
Potential areas of research interest include: identification of individual proteins; recognition of protein interactions; relative quantitation to distinguish differential expression of proteins; characterization of post-translational modifications; and qualitative or quantitative measurements at high spatial and/or temporal resolution to address the dynamics of protein interactions. One area of particular interest is the development of technologies that will permit quantitative and real-time observations, whether for clinical studies or experimental systems. Especially encouraged are applications that address the unique needs of glycomics and clinical proteomics. Informatics tools are needed for data handling and reduction, correlation of carbohydrate and protein information, and a variety of other purposes.
For more information, potential applicants should contact Dr. Danilo Tagle, Program Director, Neurogenetics Cluster, NINDS, Neuroscience Center, 6001 Executive Boulevard, Room 2133, Bethesda, MD 20892; telephone: 301-496-5745; fax: 301-402-1501; e-mail: email@example.com.
*For a more detailed description of this program announcement, please visit the NIH web site at: http://grants.nih.gov/grants/guide/pa-files/PA-04-089.html.