The National Institute of Neurological Disorders and Stroke (NINDS) invites Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) grant applications to solve the structures of membrane proteins at atomic resolution and to develop the tools needed to solve these structures. This announcement is made together with 11 other components of the National Institutes of Health (NIH). *
Membrane proteins play a crucial role in many cellular and physiological processes. They are essential mediators of material and information transfer between cells and their environment, between compartments within cells, and between compartments comprising the organ systems. Despite the importance of membrane proteins, the knowledge of their high-resolution structures and mechanisms of action has lagged far behind the knowledge of their properties in general.
Examples of types of membrane protein systems that are of particular interest include: neurotransmitter and growth factor receptors; transporters; ion pumps; voltage- and ligand-gated ion channels (such as those involved in channelopathy); trafficking proteins; mitochondrial proteins; structural proteins and other proteins involved in the normal function and pathology of cells in the central and peripheral nervous systems; proteins involved in synaptic transmission and in regulation, metabolism, homeostasis, and signaling in the brain during functions such as learning, memory, cognition, and development and aging into late life; and proteins involved in disorders of the central nervous system.
For more information, potential applicants should contact Dr. Randall Stewart, Program Director, Channels, Synapses and Circuits Cluster, NINDS, Neuroscience Center, 6001 Executive Boulevard, Room 2135, Bethesda, MD 20892; telephone: 301-496-1917; fax: 301-402-1501; e-mail: firstname.lastname@example.org.
*: For a full list of supporting NIH components and a more detailed description of this program announcement, please visit the NIH web site at: http://grants2.nih.gov/grants/guide/pa-files/PA-02-108.html.