The National Institute of Neurological Disorders and Stroke (NINDS) invites, along with 9 other components of the National Institutes of Health (NIH),* applications on novel approaches to enhance animal stem cell research.
Embryonic and other stem cells are valuable biomedical research models for the study of biological and disease processes and for the creation of disease models. Stem cells hold tremendous promise as model systems for development of therapeutics and development of replacement tissues. Thus far, embryonic stem cells have been isolated from several biomedically important nonhuman research models. However, research is needed to provide for a full array of totipotent and multipotent stem cells from nonhuman biomedical research animal models, as well as to provide the research tools to identify, characterize, and purify those cells.
Areas of potential research interest include studies to: expand the number of nonhuman animal model systems in which embryonic stem cells are available; identify, isolate, culture, and characterize multipotent stem cell populations derived from nonhuman embryonic stem cells, and from post-fetal tissue types; generate and use panels of markers for stem cell attributes common across species for use in characterization of stem cells in a range of animal species or tissues; and create universal methods of culture to maintain the undifferentiated state of embryonic or other characterized, multipotent stem cells across nonhuman animal species.
For more information, potential applicants should contact Dr. Arlene Chiu, Program Director, Repair and Plasticity Cluster, NINDS, Neuroscience Center, 6001 Executive Boulevard, Room 2206, Bethesda, MD 20892; telephone: (301) 496-1447; fax: (301) 480-1080; email: firstname.lastname@example.org.
*For a full list of supporting NIH components and a more detailed description of this program announcement, please visit the NIH web site at: http://grants.nih.gov/grants/guide/pa-files/PA-01-076.html.