Scientists at the National Institute of Neurological Disorders and Stroke (NINDS) seek children and adults with cerebral palsy (CP) for research studies. These studies (protocols #04-N-0098, #01-N-0260, and #05-N-0066) include a comprehensive rehabilitation assessment, functional magnetic resonance imaging (fMRI), electroencephalography (EEG), transcranial magnetic stimulation (TMS) of the brain, motor learning studies, and muscle reflex studies. The investigators plan to examine brain function in children and adults with CP and to examine how constraint-induced therapy affects brain function in a subset of children with hemiplegic CP. The duration of the studies will vary from a 2-day outpatient evaluation to a 3-week outpatient treatment study. Eligible participants must be 6 to 30 years of age and have either diplegic (affects the legs more than the arms) or hemiplegic (affects only one side of the body) CP.
Persons whose CP developed after 1 year of age are not eligible to take part in these studies. In addition, persons who have metal implants in their body, a severe seizure disorder, sickle cell disease, cardiac disease, another serious medical disorder, or had surgery to treat muscle stiffness in their arm or hand are not eligible. Pregnant women are not eligible to participate.
The studies will take place at the National Institutes of Health (NIH) Clinical Center in Bethesda, MD. Compensation is provided to all participants. There is no cost for participation or for any tests associated with the research. Patients who are eligible for the treatment study may have to pay for their therapy. For more information, with no obligation to participate, please contact the NIH Patient Recruitment and Public Liaison Office at 1-800-411-1222 (TTY: 1 866-411-1010). Refer to study numbers #01-N-0260, #04-N-0098, or #05-N-0066.