The National Institute of Neurological Disorders and Stroke (NINDS), the National Institute on Aging (NIA), the National Institute of Mental Health (NIMH), the National Institute on Deafness and Other Communication Disorders (NIDCD), and the Institute of Biomedical Imaging and Bioengineering (NIBIB) encourage applications for Small Business Innovation Research (SBIR) projects on the research and development of probes useful in imaging the structure and function of the brain and other parts of the nervous system.*
An emerging area of scientific opportunity is the design and use of probes to study structure and function at the molecular and subcellular level in living cells. Research and development of these technologies hold the promise of providing scientists with the capabilities to track the ebb and flow of signal transduction cascades, protein-protein interactions, movement of subcellular elements within cells, and other dynamic events.
Potential areas of research interest include: bioengineering of small-molecule, sterically benign probes that can be genetically linked to proteins that play important roles in cell function; research, development, and engineering of probes that can report quantitative information regarding particular molecular or subcellular events or structures; research and development of probes that attach to specific sites on proteins which are observable through multiple modalities; and research and development of caged molecules that provide temporally and spatially controlled release of molecular probes.
For more information, potential applicants should contact Technology Development Cluster, NINDS, Neuroscience Center, 6001 Executive Boulevard, Room 2139, Bethesda, MD 20892; telephone: 301-496-1779; fax: 301-402-1501; e-mail: email@example.com.
*For a more detailed description of this program announcement, please visit the NIH web site at: http://grants.nih.gov/grants/guide/pa-files/PA-02-029.html.