The NIH ORD and NINDS invite new and renewal cooperative agreement applications to continue the Data Management and Coordinating Center for the Rare Diseases Clinical Research Network (RDCRN). The Network has two main components: Rare Diseases Clinical Research Consortia (RDCRCs) and a Data Management and Coordinating Center (DMCC) (formerly known as Data Technology Coordinating Center, DTCC). The purpose of this Funding Opportunity Announcement (FOA) is to invite new and renewal cooperative agreement applications for the DMCC, which supports the RDCRN. A separate FOA has been published to invite new and renewal cooperative agreement applications for RDCRCs at http://grants.nih.gov/grants/guide/rfa-files/RFA-OD-08-001.html. The purpose of the Network is to facilitate clinical research in rare diseases through support for 1) collaborative clinical research in rare diseases, including longitudinal studies of individuals with rare diseases, clinical studies and/or phase I , II and II/III trials; 2) training of clinical investigators in rare diseases research; 3) pilot and demonstration projects; 4) a test bed for distributed clinical data management that incorporates novel approaches and technologies for data management, data mining, and data sharing across rare diseases, data types, and platforms; and 5) access to information related to rare diseases for basic and clinical researchers, academic and practicing physicians, patients, and the lay public. The DMCC (U54) cooperative agreement application will focus on issues relevant to item 4) and 5).