The purpose of this Funding Opportunity Announcement (FOA) is to encourage linked cooperative agreement (U01) applications from multidisciplinary and multicenter PD(s)/PI(s) to accelerate the rate of progress in understanding the underlying mechanisms that contribute to sudden unexpected death in epilepsy (SUDEP), determine risk factors for SUDEP in individuals with epilepsy, and work toward intervention(s) that prevent SUDEP. Linked applications must include an administrative core, scientific projects and may include other cores as needed to serve the scientific projects.