The purpose of this funding opportunity announcement (FOA) is to invite applications to participate as a National Data Management Center for the NINDS Stroke Trials Network. Separate FOAs have been issued to solicit applications for the Regional Coordinating Stroke Centers (RFA-NS-13-011) and the National Clinical Coordinating Center (RFA-NS-13-012). The primary goal of this network is to maximize efficiencies to develop, promote and conduct high-quality, multi-site exploratory phase 1/2 and confirmatory phase 3 clinical trials focused on key interventions, as well as biomarker-validation studies that are immediately preparatory to trials, in stroke prevention, treatment, and recovery with the objective to have a balanced portfolio between all three approaches. The network will include multiple regional coordinating stroke centers around the U.S. representing a larger number of community stroke centers all coordinated through separate National Clinical Coordinating and Data Management Centers.