The purpose of this funding opportunity announcement (FOA) is to invite applications to participate as a National Clinical Coordinating Center for the NINDS Stroke Trials Network. The primary goal of this network is to maximize efficiencies to develop, promote and conduct high-quality, multi-site exploratory phase 1, 2 and confirmatory phase 3 clinical trials focused on key interventions, as well as biomarker-validation studies that are immediately preparatory to trials, in stroke prevention, treatment, and recovery with the objective to have a balanced portfolio between all three approaches. The network will include multiple regional coordinating stroke centers with strong collaborative relationships between vascular neurology, emergency medicine, interventional neuroradiology, neurosurgery, neurointensive care, neuroimaging, stroke rehabilitation, and pediatric neurology that is coordinated through separate National Clinical Coordinating and Data Management Centers. Efficiency will be encouraged through the use of master trial agreements and a central IRB. Clinical and basic scientists at the regional coordinating stroke centers will contribute to the development of network clinical trial applications for peer review, as well as planning for execution of NINDS-funded clinical trial applications from outside of the network, including trials that result from Collaborative Research and Development Agreements between the NINDS and Industry partners. The Network will also be uniquely poised to rapidly collaborate with other existing networks, such as the NINDS Neurological Emergencies Treatment Trials Network (NETT) or international consortia to conduct larger, definitive trials of promising interventions for the treatment of stroke.
This FOA solicits applications for the National Clinical Coordinating Center for the Stroke Trials Network. A separate FOA has been issued to solicit applications for the Regional Coordinating Stroke Centers (RFA-NS-13-011) and another one will be issued for the National Data Management Center (TBD).