The purpose of this funding opportunity announcement (FOA) is to provide a competitive opportunity for a multicenter team in the USA to participate in the International Traumatic Brain Injury (InTBIR) Initiative. InTBIR is a collaboration between the NIH, the US Department of Defense (DOD), the European Commons Research Directorate (EC), and the Canadian Institutes of Health Research (CIHR) to create a large, open source international patient registry in which the variation in diagnosing and treating patients can be explored to identify those practices associated with better outcomes in otherwise similar patients.