The National Institute of Neurological Disorders and Stroke (NINDS) invites applications for participation in the Stroke Prevention/Intervention Research Program (SPIRP). The goal of the program is to develop high-impact stroke disparities interventions and research projects that have the ability to reduce stroke disparities in minority communities in the United States using effective and culturally appropriate methods. Required components include: (1) an intervention or prevention project to reduce stroke disparities in minority communities; (2) at least one additional stroke disparities research project that will address knowledge gaps or opportunities to improve the understanding of stroke disparities (race/ethnicity, rural, or low socio-economic); (3) resource-related cores that are essential to accomplishing the Specific Aims of the proposed research project and provide training/education. This FOA will utilize the U54 activity code. The U54 mechanism is a solicited, multi-component award mechanism in which substantial NIH scientific and/or programmatic involvement is anticipated throughout the program.