The purpose of this Funding Opportunity Announcement (FOA) for Exploratory Grant (P20) applications is to support exploratory collaborative research to evaluate the translational potential of a disease modification or prevention therapy in an epilepsy syndrome. In this FOA, the NINDS seeks to develop a proof-of-concept experimental framework to identify and organize research efforts on syndromes in which significant progress can be made most quickly. The goal is to encourage formation of multidisciplinary preclinical/clinical collaborations and collection of preliminary data for the clinical population, intervention(s), model(s), and/or protocol(s) that may be tested in subsequent full-scale applications. Applicants may also request support for development of administrative structures for future basic, translational and clinical efforts.