This FOA issued by the National Institute of Neurological Disorders and Stroke (NINDS) and the National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health, solicits cooperative agreement grant applications from institutions/organizations that propose to develop a redesigned and enhanced Parkinson’s Disease Data Organizing Center. NINDS and NIEHS are committed to facilitating the collection and sharing of data related to clinical and translational research in Parkinson’s disease. The goal of this program is a resource that will serve the Parkinson’s disease (PD) research community by developing an ongoing repository for data from clinical trials and clinical studies, including epidemiologic and genetic studies, related to PD, and sharing of these data to enhance research. These data may include clinical as well as associated imaging, genetic, and neuropathology data elements. In addition, the Center will link clinical data with associated genetic, biospecimen, imaging, and neuropathology data as available in other databases. The Parkinson’s Disease Data Organizing Center also will develop a flexible web-based data entry system using standardized common data elements for PD clinical research studies that can be modified by investigators for a variety of clinical research studies. The center will also maintain an up-to-date listing of resources for researchers in the scientific community. Ongoing outreach efforts should be undertaken to maximize data sharing via this resource in order to optimize research in PD. The information technology employed should serve to optimize the accessibility and usefulness of the information within the data organizing center.