The goal of this Request for Applications (RFA) is to solicit applications to elucidate the cell biology of proteins that have been implicated in Parkinson's disease (PD) through genetic findings. Studies to identify genes in PD are rapidly outpacing the cell biological studies which would reveal how these gene products are part of the disease process in Parkinson's disease. This RFA is intended to stimulate studies devoted to understanding the functional role of these proteins in cells, or how these proteins may interact or share common pivotal molecular pathways. Dissemination of these cellular pathways may reveal points at which potential interventions for Parkinson's disease could be directed. It is intended that exploratory, high-impact, focused studies supported through this RFA will generate the basis for translationally-directed research projects on PD.