This Funding Opportunity Announcement (FOA) issued by the National Institute of Mental Health (NIMH) and the National Institute of Neurological Disease and Stroke (NINDS) seeks applications for the Data Coordinating Center (DCC) of the National NeuroAIDS Tissue Consortium (NNTC). The DCC will function as part of the NNTC, a national resource that provides clinical and research data and biological specimens to accelerate discovery research for HIV-associated central nervous system (CNS) and peripheral nervous system (PNS) diseases. It will support the NNTC Clinical Sites that are funded via the companion FOA (RFA-MH-13-070). The DCC works cooperatively with the NNTC Clinical Sites to provide (1) management and database capabilities to ensure effective clinical and brain banking operations and (2) scientific expertise in biostatistics and HIV epidemiology to enable broad analysis of the NNTC clinical database and to aid in post award statistical analysis of recruitment and retention goals for the NNTC cohort. In this consortium, the NNTC Clinical Sites will have all patient contact which will include all clinical assessments ante-mortem. The NNTC Clinical Sites will also be responsible for the collection and housing of post mortem clinical specimens. The DCC will serve as a data repository which will include the clinical assessment data and data obtained post mortem including brain pathology reports, laboratory tests conducted on the collected specimens/fluids, a comprehensive inventory of those specimens housed at each NNTC Clinical Site, and research data, such as bioinformatics datasets.