NINDS Neuroscience Funding Announcements

Viral and Host Genetic Factors Regulating HIV-Associated CNS Disease

Funding Contact(s): May Wong, Ph.D.
Funding Categories: Neural Environment

Brief Description:
The National Institute of Mental Health (NIMH) and The National Institute of Neurological Disorders and Stroke (NINDS) solicit research grant applications to support studies focused on viral and host genetic factors involved in HIV-1 Associated Neurocognitive Disorders (HAND) in the setting of highly active anti-retroviral therapy (HAART). Recent clinical studies indicate that over 50% of HIV-infected patients manifest HAND despite receiving HAART. The focus of this initiative is to encourage studies to discover novel genetic paradigms that may account for the interactions between the virus, the host, and the therapeutic drugs in the central nervous system (CNS) that result in the pathogenesis, progression, and clinical manifestations of HAND. The use of state-of-the-art genetic approaches (including transcriptomics, phenomics, epigenomics, whole genome association studies, next generation sequencing, exome sequencing, & systems biology) to identify and validate (including in vitro models, animal models, & human samples) viral and host genetic factors which influence the pathophysiology of HAND are encouraged.

Grant Mechanism: R01
NIH Guide: RFA-MH-11-020
Release Date: 2010-07-29
Expiration Date: 2011-01-07

Grant Mechanism: R21
NIH Guide: RFA-MH-11-021
Expiration Date: 2011-01-07