This RFA provides support for the establishment of a Resuscitation Research Consortium to conduct clinical research in the areas of cardiopulmonary arrest and traumatic injury leading to arrest. This Clinical Research Consortium (the Consortium), consisting of up to seven Regional Clinical Centers (RCCs) and a Data and Coordinating Center (DCC), will provide the necessary infrastructure to conduct multiple collaborative trials to aid rapid translation of promising scientific and clinical advances to improve resuscitation outcomes.