The purpose of this Request for Applications (RFA) is to establish a research network that will contribute to improved management of type1 diabetes and hypoglycemia prevention. The National Institute of Child Health and Human Development (NICHD), National Institute of Neurological Disorders and Stroke (NINDS), and National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) invite applications from investigators willing to participate in a cooperative research network designed to reduce the incidence of hypoglycemia in children and young adults. The network will use new tools to evaluate factors and mechanisms contributing to hypoglycemia and will set up clinical trials to test novel therapies, prevention strategies and devices designed to focus on hypoglycemia prevention for individuals with type 1 diabetes. The clinical research network will provide the necessary infrastructure to develop, coordinate, and conduct multiple collaborative clinical protocols. Results of network studies are expected to be widely disseminated and to improve the scientific basis of care for individuals affected with type1 diabetes. NIH project scientists will assist Principal Investigators of the research network in identifying research topics of high priority, and in designing and implementing protocols in the evaluation and implementation of optimum management of type1 diabetes. It is anticipated that approximately five clinical centers will participate in the program.