The overall purpose of the MAPP Network is to conduct multi-disciplinary, collaborative, multi-site basic, translational, and clinical research addressing UCPPS. It is anticipated that these studies will increase our understanding of the pathophysiology, biologic and behavioral risk factors, natural history, and genetics of UCPPS. An important focus of the MAPP Network will be investigation of the biologic and behavioral relationships between IC/PBS and CP/CPPS and other frequently related symptom-based conditions. Related chronic pain syndromes of primary interest of this Network are fibromyalgia, irritable bowel syndrome, and chronic fatigue syndrome which have sufficient scientific evidence. Epidemiologic evidence is less compelling for vulvodynia and migraine headache, but these may be studied if adequate scientific justification is provided. The ultimate aim is to provide findings useful for development of future prevention or treatment strategies.