Hypoglycemia in Patients with Type I Diabetes
Funding Contact(s): Merrill Mitler, Ph.D.
Funding Categories: Neural Environment
Brief Description:
Inviting applications for basic and clinical studies to enhance understanding and prevention of hypoglycemia in patients with
diabetes. Large clinical trials have demonstrated the efficacy of intensified glucose control in the prevention of the long-term
vascular complication of diabetes. However, episodes of severe hypoglycemia may complicate intensified treatment and are often
a major obstacle to the achievement of euglycemia in many patients. This RFA seeks basic and clinical studies to 1) enhance
understanding of how the brain and other critical tissues sense and respond to hypoglycemia, 2) delineate the effects of hypoglycemia
on brain function and 3) develop improved methodologies to prevent hypoglycemia, based on an understanding of physiological
glucose sensing and counterregulation.