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NINDS Neuroscience Funding Announcements



Tools for Insertional Mutagenesis in the Mouse

Funding Contact: NINDS Funding Coordinator
Funding Categories: Neurogenetics

Brief Description:

This RFA solicits proposals for development of tools and techniques for the establishment of random and targeted sequence-tagged insertion libraries of embryonic stem (ES) cells that can be used to generate mutant mice in which the expression of the tagged gene could be controlled temporally and spatially. The development of such a resource for wide distribution to the scientific community would make it possible to scan the sequence database for any gene of interest and order the corresponding targeted ES cell line. Ideally, the insertional mutagenesis system developed would permit a wide range of genetic analyses and manipulations, including enhancer-trapping, conditional knockouts, conditional expression or overexpression, etc. It also would permit the larger community of investigators to utilize genomic resources efficiently.



NIH Guide: RFA-DA-01-011
Release Date: 2001-01-25
Expiration Date: 2001-04-12