invites applications proposing clinical and translational research in multiple sclerosis (MS) that target the neurodegenerative aspect of this disease. Applicants are expected to propose activities that are directly focused on the development of neuroprotective and regenerative therapies for MS. Applications in basic neuroscience or glial biology are not covered under this PAS. Applications for clinical trials and interventional studies are directed to use the funding mechanisms and opportunities listed at http://www.ninds.nih.gov/funding/areas/clinical_trials/index.htm