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NINDS Neuroscience Funding Announcements



Neurovascular Mechanisms of Brain Function and Disease (R21)

Funding Contact: NINDS Funding Coordinator
Funding Categories: Neural Environment

Brief Description:

The goal of this Program Announcement with set-aside funds (PAS) is to invite applications for studying the integration of neurobiological and cerebrovascular mechanisms in the adult, aged and pediatric brain in health and disease. This PAS encourages studies focused on improving our understanding of the dynamic interactions within the neurovascular unit (NVU), a construct consisting of brain microvascular endothelium, glia, neurons and the extracellular matrix that maintains spatial relations among them. Knowledge of these interactions has the potential to stimulate new strategies for basic, translational and clinical research in many neurological disorders, including stroke, vascular dementia, and intracerebral hemorrhage. Among the challenges to be addressed are: generate new hypotheses and conduct exploratory work on microvessel–neuron communication; increase our knowledge about cell-cell signaling and how insults to the endothelium affect parenchymal cell damage, which applies not only to stroke, but may also contribute to understanding neurological disorders in which vascular changes are observed; and, elucidate mechanisms by which neurons communicate with blood vessels through interactions with non-neuronal cells in the microenvironment including endothelium, pericytes, astrocytes, oligodendrocytes and microglia.



Grant Mechanism: R21
NIH Guide: PAS-06-200
Release Date: 2006-03-07
Expiration Date: 2007-03-17