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NINDS Neuroscience Funding Announcements

Interactions Between Stem and Progenitor Cells and the Microenvironment In Vivo (R01)

Funding Contact(s): David Owens, Ph.D.
Funding Categories: Repair and Plasticity

Brief Description:

Inviting applications for studies on the cellular and molecular signaling between the local environment within organisms and stem and progenitor cells that are either introduced as transplants or are normally resident within host tissues and organs. The objective of this initiative is to promote a thorough exploration and characterization of the bi-directional communication between multipotent cells and the three-dimensional local milieu or niche that they encounter in vivo under normal and compromised states, such as with aging or following injury, disease or drug exposure. Of particular interest is the rigorous characterization of how interactions with localized cues in space and time regulate stem cell survival, migration, replication and 'plasticity' in the nervous system and other parts of the body. Projects that address comparisons between the responses of stem cells within niches in the developing and mature or aging nervous system in vivo, or in host microenvironments modified by injury, disease, or by exposure to drugs and alcohol would also be directly relevant to this Program Announcement with Set-aside (PAS), as are studies to compare different classes of stem cells or progeny at progressively more advanced stages of differentiation when placed in the same sites in vivo.

Grant Mechanism: R01
NIH Guide: PAS-05-092
Release Date: 2005-04-21
Expiration Date: 2007-01-03