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NINDS Neuroscience Funding Announcements

Glial Cell Inflammatory Mechanisms of HIV-1 Induced Cell Injury in the Nervous System

Funding Contact: NINDS Funding Coordinator
Funding Categories: Neural Environment

Brief Description:

Inviting applications to promote research into the role of neuroinflammation in the initiation and expansion of cellular injury and death in the context of HIV-1 infection of the central nervous system (CNS). Recent evidence indicates that microglial and astrocytic activation results in the release of excitotoxins, arachidonic acid metabolites, reactive oxygen species, cytokines and chemokines that lead to neurodegeneration and cognitive impairment in HIV-1 infected individuals. The intent of this PAS is to intensify interest and investigator-initiated research, to attract new investigators to this field, and to mobilize interdisciplinary approaches.

Grant Mechanism: R21
NIH Guide: PAS-03-084
Release Date: 2003-03-20
Expiration Date: 2005-11-01