With this Program Announcement, the National Institute of Neurological Disorders and Stroke (NINDS) invites research grant applications (R01) that address the development and treatment of dopamine-induced dyskinesias, a major complication of current pharmacotherapy of Parkinson's disease. The purpose of this initiative is to 1) support the study of the pathophysiologic basis of dopamine-induced dyskinesias; and 2) support the study of non- dopaminergic pharmacologic agents for the treatment of dopamine-induced dyskinesias.