Participating Institutes and Centers (ICs) of the National Institutes of Health (NIH) invite applications for R01 awards to support Bioengineering Research Partnerships (BRPs) for basic bioengineering research addressing important biological or medical research problems. A BRP is a multidisciplinary research team applying an integrative, systems approach to develop knowledge and/or methods to prevent, detect, diagnose, and treat disease and understand health and behavior. The partnership must include bioengineering expertise in combination with basic and/or clinical investigators. A BRP may propose design-directed or hypotheses-driven research in universities, national laboratories, medical schools, private industry and other public and private entities.