To facilitate the cooperation and partnering of public and private funding organizations, universities, academic medical centers, research institutes, contract research organizations, biotechnology companies, and pharmaceutical companies, NINDS has formed the Neurology Network of Excellence in Clinical Trials (NeuroNEXT, www.NeuroNEXT.org). NeuroNEXT has a Clinical Coordinating Center (CCC), a Data Coordinating Center (DCC) and a group of 25 geographically distributed clinical sites. This FOA provides one of a set of three different means by which teams of investigators can gain access to the NeuroNEXT infrastructure. This FOA uses the U01 cooperative agreement mechanism and is open to all eligible applicants, as defined in Section III. Small businesses may wish to consider applying through PAR-11-345 "NeuroNEXT Small Business Innovation in Clinical Trials (U44)". For-profit organizations and Non-profits other than Institutions of Higher Education may wish to consider applying through PAR-11-344 "NeuroNEXT Infrastructure Resource Access (X01)". To foster the development of clinical trialists, the NeuroNEXT investigators who have been selected for their experience and training in neurological clinical research will provide a source of strong mentorship and support to investigators who are early in their careers as approved studies are implemented within the infrastructure.