The National Institute of Neurological Disorders and Stroke (NINDS) invites applications for Center Core Grants to support the NINDS mission, which is to reduce the burden of neurological disease. In pursuit of this mission, NINDS supports basic, translational, and clinical research on the normal and diseased nervous system. For an overview of NINDS, with links to more information, see http://www.ninds.nih.gov/about_ninds/ninds_overview.htm. The Centers will provide cutting edge resources and facilities to investigators who have existing NINDS-funded research projects, and to other investigators pursuing research consistent with the NINDS mission. The Centers should enhance the effectiveness of ongoing research and facilitate new research directions. This support is intended to increase resource accessibility and to capitalize on potential economies and synergies that would not be attained through independent funding of separate research projects. To receive a Center Core Grant, an institution or consortium must support at least six Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) who hold qualifying NINDS-funded research projects at the time of application submission. Qualifying projects include R01 and other larger scale awards, as specified in Section III.3. Additional Information on Eligibility.