The purpose of this funding opportunity announcement (FOA), issued by NINDS, is to invite new and renewal applications to participate as Clinical Site Hubs in the Neurological Emergencies Treatment Trials (NETT) Network. The goal of this existing network is to develop and widely implement efficacious treatments for patients with a broad spectrum of neurological emergencies in order to decrease the morbidity and mortality associated with neurological disease. Their objective is to conduct multiple, large, streamlined phase III clinical trials involving neurological emergencies.