This Funding Opportunity Announcement (FOA) requests applications for projects intended to complete preliminary steps in the pipeline for the pre-clinical development of therapeutics for neurological disorders. Such projects, if successful, should lead directly to a subsequent project that will include all remaining activities for submission of an Investigational New Drug (IND) or Investigational Device Exemptions (IDE) application to the Food and Drug Administration (FDA). Only Aims required for therapy development can be supported in this program. This program excludes clinical research, basic research and studies of disease mechanism. Mechanism of Support. This FOA will use the NIH Exploratory/Developmental (R21) grant mechanism.