Purpose. This funding opportunity announcement (FOA), from the National Institute of Neurological Disorders and Stroke (NINDS) encourages applications for projects intended to complete preliminary steps in the pipeline for the preclinical development of therapeutics to cure epilepsy, prevent the emergence of epilepsy following brain injury (including status epilepticus, traumatic brain injury, stroke, encephalitis, or other injury) or in other high-risk groups, or to better treat individuals with intractable epilepsy. Such projects, if successful, should lead directly to a subsequent project that will include all remaining activities for submission of an Investigational New Drug (IND) or Investigational Device Exemptions (IDE) application to the Food and Drug Administration (FDA). Only Aims required for therapy development can be supported in this program. This program excludes clinical research, basic research, and studies of disease mechanisms.