The National Institute of Neurological Disorders and Stroke (NINDS), the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), and the National Institute of Child Health and Human Development (NICHD) solicit applications for translational research projects in muscular dystrophy. Several emerging pathways to treatment of muscular dystrophy show promise, ranging from palliative therapies that can markedly delay onset or progression of the disease to genetic or stem cell approaches that may reverse or eliminate the condition. The objective of this initiative is to encourage the pursuit of a broad range of translational research strategies for therapeutic development in muscular dystrophy. This Funding Opportunity Announcement (FOA) solicits exploratory/developmental applications that will provide the leads, tools, and resources needed for a subsequent therapy development project. Applications are encouraged for translational research exploratory/developmental projects for any one or more of the muscular dystrophies.