Each center may contain basic, translational, or clinical research, or, proportions of each that are appropriate for the research objectives. Research objectives should emphasize basic, translational or clinical studies of Parkinson’s disease, parkinsonisms, and related disorders. Emphasis is placed on multi-disciplinary and collaborative studies that can best be carried out in a Center setting. The organizational structure of the Center should be flexible to allow the expeditious translation of new scientific findings and new technological developments to clinical research.