The National Institute of Neurological Disorders and Stroke and the National Institute of Arthritis and Musculoskeletal and Skin Diseases solicit applications for translational research projects in muscular dystrophy. Several emerging pathways to treatment of muscular dystrophy show promise, ranging from palliative therapies that can markedly delay onset or progression of the disease to genetic or stem cell approaches that may reverse or eliminate the condition. The objective of this initiative is to encourage the pursuit of a broad range of translational research strategies for therapeutic development in muscular dystrophy. This Program Announcement (PA) solicits applications for cooperative agreements that will support milestone-driven projects focused on the identification and pre-clinical in vitro or animal testing of new therapeutics. Applications are encouraged for translational research projects for any one or more of the muscular dystrophies.