The National Institute of Neurological Disorders and Stroke (NINDS) invite grant applications for Specialized Programs of Translational Research in Acute Stroke (SPOTRIAS). The intent of the SPOTRIAS is to support a collaboration of clinical researchers from different specialties whose collective efforts will lead to new approaches to early diagnosis and treatment of acute stroke patients. The goal of the SPOTRIAS will be to reduce the disability of and mortality in stroke patients by promoting rapid diagnosis and effective interventions. Eligible institutions must be able to deliver rapid treatment for acute stroke and to conduct the highest quality translational research on the diagnosis and treatment of acute ischemic and hemorrhagic stroke. SPOTRIAS grants will require that a minimum number of stroke patients be treated two hours after the onset of their symptoms. Another important function of SPOTRIAS is to establish a program to recruit and train the next generation of stroke researchers. Eligible organizations include: For-profit or non-profit domestic organizations, public or private institutions, such as universities, colleges, hospitals, and laboratories, Units of State and local governments, and eligible agencies of the Federal government. Any individual with the skills, knowledge, and resources necessary to carry out the proposed research is invited to work with their institution to develop an application for support. The support for SPOTRIAS is through an NIH specialized center grant (P50) mechanism. The maximum allowable direct cost per year for a SPOTRIAS will be $1,500,000.