The National Institute of Neurological Disorders and Stroke (NINDS) and the National Institute of Deafness and Other Communication Disorders (NIDCD) invite qualified investigators to submit grant applications for the establishment of National Centers for Neurofibromatosis Research. Recent discoveries have created important opportunities for basic, translational, and clinical research on the neurofibromatoses. The purpose of this Program Announcement (PA) is to encourage the formation and development of research centers that can capitalize on these opportunities, and ultimately develop therapeutic interventions for neurofibromatosis patients. These centers are intended to provide focused expertise and resources, and establish a multi-disciplinary environment that will accelerate research progress.