The purpose of this initiative is to encourage and support investigator- initiated research on neuroscience informatics (neuroinformatics). This research will lead to the development of new web based databases, analytical tools, and knowledge management systems to foster sharing of data for all domains of neuroscience research. This program combines neuroscience and informatics (neuroinformatics) research to develop and apply advanced tools and approaches essential for efficient understanding of the structure, function and development in health and disorders of the nervous system, from the genetic to whole systems level.