The National Institute on Aging (NIA), in collaboration with the National Institute of Child Health and Human Development (NICHD), the National Institute on Deafness and Other Communication Disorders (NIDCD), the National Institute of Dental and Craniofacial Research (NIDCR), the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), the National Eye Institute (NEI), and the National Institute of Neurological Disorders and Stroke (NINDS), invites grant applications in the area of age-related changes in multiple sensory systems. A major goal of aging research is directed toward the public health issue of maintaining functional independence of the elderly individual. Aside from specific diseases, sensory declines represent a broad category of normal age-related changes that can lead to diminished quality of life for the elderly individual, loss of independence, and increased costs for society as a whole. Although declines in single sensory systems have been studied, there is less information about the effects of concurrent changes in multiple systems, at either the population or basic science level. The purpose of this program announcement is to stimulate research investigating: (1) the prevalence and extent of concurrent declines in multiple sensory systems in the elderly, (2) the effects such declines might have on the functional capacities of the individual, and (3) the underlying mechanisms responsible for commonalities in age-related sensory changes at central nervous system, cellular, molecular or genetic levels.