This Funding Opportunity Announcement (FOA), issued by the National Institute of Mental Health (NIMH), National Institute on Aging (NIA), National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institute on Drug Abuse (NIDA), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institute on Neurological Disorders and Stroke (NINDS), and the National Cancer Institute (NCI) solicits exploratory and developmental research grant applications to study neuroimmune molecules and mechanisms involved in regulating normal and pathological functions of the central nervous system (CNS).