This Funding Opportunity Announcement (FOA), issued by the National Institute of Mental Health (NIMH), National Institute on Aging (NIA), National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institute on Drug Abuse (NIDA), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institute on Neurological Disorders and Stroke (NINDS), National Cancer Institute (NCI), and National Center for Complementary and Alternative Medicine (NCCAM) solicits research grant applications to study neuroimmune molecules and mechanisms involved in regulating normal and pathological functions of the central nervous system (CNS).