Structural Biology of Membrane Proteins (R01)
Funding Contact(s): Randall Stewart, Ph.D.
Funding Categories: Channels, Synapses and Circuits
Brief Description:
This PA solicits applications to develop research and methods to enhance the rate of membrane protein structure determination
and to determine specific membrane protein structures. Innovative methods for expression, oligomerization, solubilization,
stabilization, purification, characterization, crystallization, isotopic labeling, and structure determination of unique and
biologically significant membrane proteins by x-ray diffraction, nuclear magnetic resonance (NMR), electron microscopic,
mass spectrometry, and other biophysical techniques are encouraged. Projects that will lead in the near term to determining
the structures of biologically important membrane proteins are also encouraged.