This Program Announcement replaces PA-02-003. The purpose of this Program Announcement (PA) is to encourage submission of new research project grant (R01) and exploratory/developmental grant (R21) applications to research and develop innovative technologies, methodologies, or instrumentation for basic or clinical studies of the brain or behavior in human or non-human animals. Also solicited are applications for support to research, develop, and significantly enhance existing technologies that are important to understanding the brain or behavior.