this Program Announcement (PA) solicits Small Business Innovation Research (SBIR) grant applications proposing the development of PET and SPECT probes for molecular targets (e.g., receptors, intracellular messengers, disease-related proteins) that are of broad interest to the neuroscience research community. These radiotracers will be used for neuroimaging as well as potential biological markers and surrogate endpoints for translational and clinical research, drug discovery and development, and clinical trials. Also appropriate for this PA are applications proposing research and development of new technologies for radiotracer development.